Individual data revealed that depression remains a major psychiatry condition in perinatal period. However, its burden haven not yet been comprehensively assessed nationally. This review determined the magnitude of perinatal depression and major factors leading to the episode of depressive disorder among mothers in Ethiopia. The study indicated that, the pooled prevalence of perinatal depression was 25.8% [95% CI, 24.6%-27.1%]. Predisposing factors such as, having obstetric complications in previous and/or this pregnancy [RR: 2.74 (95% CI, 1.48-5.06), I2 = 67.7%], and having unplanned pregnancy [RR: 2.73 (95% CI, 2.11-3.53), I2 = 0%] were the major factors associated with perinatal depression. To attenuate these factors and to realize the sustainable development goals (SDGs) outlined by united nation, much attention should be given to improve maternal mental health through reduction of identified modifiable factors.
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